Error: The underlying connection was closed: An unexpected error occurred on a send - in the Sphere Connector

After clicking on Sphere in the Sphere Connector for The Raiser's Edge, you receive the error:

The underlying connection was closed. An unexpected error occurred on a send.
This can occur after TLS 1.0 has been disabled on the Sphere servers. Download and install the latest version of the Sphere Connector to resolve this issue, which contains all fixes from previous patches.

Environment

 Blackbaud Sphere
 Sphere Connector 4.1.4.9

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